Comprehensive review on characterizations and application of gastro-retentive floating drug delivery system
نویسندگان
چکیده
Current pharmaceutical situation focuses on the preparation of gastro-retentive floating drug delivery system (GRFDDS). This systems has gained noteworthy interest in past decades. These are low density that float over gastric contents and remain buoyant stomach for a prolonged period time without affecting emptying rate. GRFDDS is used to delay residence stomach. The controlled retention solid dosage forms may be achieved by mechanism mucoadhesion, floatation, sedimentation, expansion, modified shape or administration pharmacological agents delaying emptying. results targeting release at specific site systemic local effects. GRDDS overcome challenges associated with conventional oral absorption improve bioavailability particular substance. Some have shown capability accommodate these variations release. review mainly characterizations application systems.
منابع مشابه
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ژورنال
عنوان ژورنال: GSC Advanced Research and Reviews
سال: 2021
ISSN: ['2582-4597']
DOI: https://doi.org/10.30574/gscarr.2021.7.1.0070